发明名称 |
ANTICALCIFICATION TREATMENT FOR ALDEHYDE-TANNED BIOLOGICAL TISSUE |
摘要 |
A method of treating aldehyde-tanned biological tissue minimizes in vivo calcification and reduces cytotoxicity without impairing the mechanical strength of the tanned tissue. The method includes the step of treating the aldehyde-tanned biological tissue with at least one liquid polyol having formula (I), where R is CH2OH or an alkyl group, and R' is H, an alkyl group or an O-acyl where the acyl is C2-C9 or a carboxyalkyl; or formula (II) where R is H or an alkyl group, and R' is H, an alkyl group, O-alkyl or O-carboxyalkyl. Preferred polyols are propylene glycol, 1,3-propanediol, 2,3-butylene glycol and glycerol, and the polyol is preferably a diol. |
申请公布号 |
WO9319209(A1) |
申请公布日期 |
1993.09.30 |
申请号 |
WO1993US02090 |
申请日期 |
1993.03.08 |
申请人 |
SEIFTER, ELI;FRATER, ROBERT, WILLIAM, MAYO |
发明人 |
SEIFTER, ELI;FRATER, ROBERT, WILLIAM, MAYO |
分类号 |
A61L27/00;A01N1/02;A61L27/36;C14C3/08;C14C3/16 |
主分类号 |
A61L27/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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