发明名称 |
Substituted pipecolinic acid derivatives as HIV protease inhibitors. |
摘要 |
<p>Disclosed herein are compounds of formula 1 <CHEM> wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an optionally mono- or disubstituted carbamoyl; B is absent or an amino acid residue, for example, Val or Asn; R<1> is hydrogen or a ring substituent, for example, fluoro or methyl; R<2> is alkyl; and Y is a ring substituent, for example, phenoxy, 2-pyridinylmethoxy, phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.</p> |
申请公布号 |
EP0560268(A1) |
申请公布日期 |
1993.09.15 |
申请号 |
EP19930103712 |
申请日期 |
1993.03.09 |
申请人 |
BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. |
发明人 |
ANDERSON, PAUL CATES;SOUCY, FRANCOIS;YOAKIM, CHRISTIANE;LAVALLEE, PIERRE;BEAULIEU, PIERRE LOUIS |
分类号 |
A61K31/506;A61P31/12;A61P31/18;A61P37/04;A61P43/00;C07D211/56;C07D211/60;C07D401/06;C07D401/12;C07D401/14;C07D403/12;A61K31/44;A61K31/4427;A61K31/445;A61K31/451;A61K31/452;A61K31/4545;A61K31/47;A61K31/505 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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