| 摘要 |
PCT No. PCT/SE89/00642 Sec. 371 Date May 10, 1991 Sec. 102(e) Date May 10, 1991 PCT Filed Nov. 9, 1989 PCT Pub. No. WO90/05303 PCT Pub. Date May 17, 1990.A sensing surface suitable for use in a biosensor, comprising: a film of a free electron metal selected from the group consisting of copper, silver, aluminum and gold; and a densely packed monolayer of an organic molecule X-R-Y coated on one of the faces of said film where X is a group selected from the group consisting of asymmetrical or symmetrical disulfide (-SSR'Y', -SSRY, sulfide (-SR'Y', -SRY), diselenide (-SeSeR'Y', -SeSeRY), selenide (SeR'Y', -SeRY), thiol (-SH), isonitrile, nitro (-NO2), selenol (-SeH), trivalent phosphorus compounds, isothiocyanate, xanthate, thiocarbamate, phosphine, thio acid and dithio acid (-COSH, -CSSH) where R and R' are hydrocarbon chains optionally interrupted by hetero atoms, of a length exceeding 10 atoms, wherein in the case of an asymmetrical molecule, R' or R may be H, and Y and Y' are active groups for covalently binding ligands or a biocompatible porous matrix.
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