| 摘要 |
<p>The object of the present invention is to provide a polymer matrix type pharmaceutical preparation for sustained release of a drug which can realize the desired release properties and a process for producing the same. A pharmaceutical preparation for sustained release of a drug which comprises as a main base hydroxypropylmethylcellulose, wherein the drug is released according to the prescribed formula. Control of release is done by regulating the substitution degree and mean molecular weight of hydroxypropylmethylcellulose and appropriately containing therein the water-soluble additive. Such the pharmaceutical preparation can be obtained by applying the partial wet granulation process thereto in which a drug is wet-granulated using a binder and thereafter this is dried to obtain a drug granule, and thereafter mixing hydroxypropylmethylcellulose and water-soluble ingredient therein and compressing the mixture.</p> |
