OPTICALLY ACTIVE INTERMEDIATE AND PRODUCTION THEREOF.

摘要

A process for synthesizing an optically active starting material, represented by general formula (I), for various medicines with a high optical purity in a good yield, wherein R<1> represents hydrogen or hydroxyl-protecting group: * represents an asymmetric carbon atom; R<2'> represents hydrogen or optionally substituted lower alkyl; and Q represents -C=P(Ph)3, -CH2P(O)(OMe)2 or -CN2S(O)Me. More particularly, an intermediate for the synthesis of an optically active compound useful for inhibiting the activity of HMG-CoA reductase to thereby inhibit the biosynthesis of cholesterol; and a process for producing the intermediate.