发明名称 |
METHOD FOR MAKING UNIVERSAL DONOR CELLS |
摘要 |
Transplantation antigen-depleted cells and methods for making such cells from a target cell are provided. The transplantation antigen-depleted cell is made by exposing a target cell to an oligonucleotide capable of binding to a transplantation antigen nucleotide sequence. The oligonucleotide is capable of binding to the nucleotide sequence according to Watson-Crick or triplex binding rules. Preferred transplantation antigens are the MHC class I or II antigens. Oligonucleotides useful in practicing this method are also provided.
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申请公布号 |
CA2126692(A1) |
申请公布日期 |
1993.08.05 |
申请号 |
CA19932126692 |
申请日期 |
1993.01.29 |
申请人 |
UNIV CALIFORNIA |
发明人 |
WEISS TANIA L;GAROVOY MARVIN R;HUNT ANTHONY;HUEY BING;TAM SCHUMAN |
分类号 |
C12N15/09;A61K31/70;A61K48/00;A61P37/00;C07H21/04;C12N5/10;C12N15/113;(IPC1-7):C12N5/08;C07H21/00;A61K35/12 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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