PRODUCTION OF 2',3'-DIDEOXYPURINE NUCLEOSIDES

摘要

PURPOSE:To obtain the subject compounds useful as an antiviral agent in good yield for a short time by reacting a purine compound with dideoxycytidine, etc., in the presence of phosphoric acid (salt) at a specific concentration using a pyrimidine nucleoside phosphorylase, etc. CONSTITUTION:A purine compound expressed by formula I (R1 is OH or halogen; R2 is H or amino) is made to react with 2',3'-dideoxycytidine, 2',3'- dideoxyuridine or 3'-deoxythymidine in the presence of a phosphoric acid (salt) at 1-20 mM concentration using a pyrimidine nucleoside phosphorylase or a purine nucleoside phosphorylase to afford the objective compounds expressed by formula II.