| 摘要 |
PURPOSE:To provide a new itaconic acid derivative useful as a medicine, especially having a hypoglycemic activity and useful as a diabete. CONSTITUTION:An itaconic acid derivative of formula I (R is H, 1-6C alkyl; A is halogen or phenyl, heterocyclic or 3-8C cycloalkyl which may be substituted with a 1-4C alkyl or 1-4C alkoxy; B is monocyclic amino which, if necessary, has an unsubstituted bond in the ring and which may be substituted with a 1-6C alkyl or aryl) and its salt, e.g. (E)-2-benzilidene-3-(1-pyrrolidinylcarbonyl) propionic acid. The compound of formula I is obtained e.g. by reacting itaconic anhydride with an amine compound of formula III and, if necessary, esterifying the reaction product. An ester compound having the 1-6C alkyl as the R among the compound of formula I is obtained by reacting the reactive functional derivative of an itaconic acid monoester compound of formula IV (R<4> us 1-6C alkyl) with the compound of formula III. |
