发明名称 |
PAPILLOMAVIRUS E2 TRANS-ACTIVATION REPRESSORS |
摘要 |
This invention relates to E2 trans-activation repressors which interfere with normal functioning of the native full-length E2 transcriptional activation protein of the papillomavirus. Native full-length E2 trans-activation protein activates transcription of papillomavirus only through binding to DNA, and it binds to DNA only in the form of a pre-formed homodimer-a pair of identical polypeptide subunits held together by non-covalent interactions. The E2 trans-activation repressors of this invention are proteins, polypeptides or other molecules that dimerize with full-length native E2 polypeptides to form inactive heterodimers, thus interfering with the formation of active homodimers comprising full-length native E2 polypeptides, thereby repressing papillomavirus transcription and replication. The E2 trans-activation repressors of this invention are advantageously used in the treatment of papillomavirus infections and their associated diseases.
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申请公布号 |
US5219990(A) |
申请公布日期 |
1993.06.15 |
申请号 |
US19910646998 |
申请日期 |
1991.01.28 |
申请人 |
BIOGEN, INC.;NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. |
发明人 |
ANDROPHY, ELLIOT J.;BARSOUM, JAMES G. |
分类号 |
A61K38/00;A61P31/12;C07K14/025;C07K14/16;C12N1/19;C12N1/21;C12N15/09;C12N15/37;C12P21/02;C12R1/19;C12R1/85 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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