ASYMMETRIC CHEMICAL SYNTHESIS AND INTERMEDIATES FOR MAKING ANTIFUNGAL COMPOUNDS

摘要

Intermediates of the structural formula II, III, IV, VIII, XI, or XII, wherein said compound has an asymmetric center(s) as indicated by the single asterisk (*) and the double asterisk (**) and wherein the compound is substantially free from compound(s) having the same chemical structure but having other absolute stereochemical configurations at the asterisked carbon centers: or a pharmaceutically acceptable salt thereof, wherein Ar represents phenyl, substituted phenyl, 3-thienyl, substituted 3- thienyl, 3-furanyl or substituted 3-furanyl; R represents alkyl or cycloalkyl; R<1> represents H or alkyl; X represents chloro, bromo or iodo; X<1> represents OH, chloro, bromo, iodo or P<1> where P<1> represents alkoxy-substituted phenyloxy, benzyloxy, substituted benzyloxy, acyloxy, alkylthio, phenylthio, substituted phenylthio or -NHP<2> where P<2> is an amino protecting group; and P represents H or a hydroxy protecting group; and processes for making chemically pure, enantiomeric antifungal compounds.