发明名称 |
METHODS FOR THE PREPARATION OF (3R,3aS,6aR) HEXAHYDRO-FURO[2,3-b]FURAN-3-OL |
摘要 |
The present invention relates to methods for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol as well as a novel intermediate, (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one for use in said methods. More in particular the invention relates to a stereoselective method for the preparation of diastereomerically pure (3R,3aS,6aR) hexahydro-furo[2,3-b]furan-3-ol, as well as methods for the crystallization of (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one and for the epimerization of (3aR,4R,6aS) 4-methoxy-tetrahydro-furo[3,4-b]-furan-2-one to (3aR,4S,6aS) 4-methoxy-tetrahydro-furo[3,4-b]furan-2-one. |
申请公布号 |
LT1732931(T) |
申请公布日期 |
2016.09.12 |
申请号 |
LT20050729507T |
申请日期 |
2005.03.31 |
申请人 |
Janssen Sciences Ireland UC |
发明人 |
QUAEDFLIEG, Peter, Jan, Leonard, Mario;KESTELEYN, Bart, Rudolf, Romanie;VIJN, Robert, Jan;LIEBREGTS, Constantinus, Simon, Maria;KOOISTRA, Jacob, Hermanus, Matheus, Hero;LOMMEN, Franciscus, Alphons, Marie |
分类号 |
C07D493/04;C07D307/20;C07H15/04 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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