发明名称 |
Regioselective chemical modification of monoclonal antibodies |
摘要 |
A method of selectively modifying an immunoglobulin having at least one Fab region and at least one Fc region, each region having an isoelectric point wherein said isoelectric point of the Fab fragment of said immunoglobulin is different than the isoelectric point of the Fc fragment of the immunoglobulin, said method comprising modification of the immunoglobulin at a pH between the respective isoelectric points of the Fab and Fc fragments of the immunoglobulin.
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申请公布号 |
US5208008(A) |
申请公布日期 |
1993.05.04 |
申请号 |
US19900613127 |
申请日期 |
1990.11.14 |
申请人 |
UNIVERSITY OF PITTSBURGH |
发明人 |
RANADIVE, GIRISH;ROSENZWEIG, HOWARD S.;EPPERLY, MICHAEL;BLOOMER, WILLIAM |
分类号 |
C07K1/00;C07K1/107;C07K16/00 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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