LEUKOCYTE ADHESION MOLECULE-1 (LAM-1) AND LIGAND THEREOF

摘要

A leukocyte-associated cell surface protein LAM-1 (leukocyte adhesion molecule-1), which contains domains homologous with binding domains of animal lectins, growth factors, and C3/C4 binding proteins; the specific domains of the LAM-1 protein; ligand binding fragments of the LAM-1 protein; and the genomic DNA sequences encoding the LAM-1 protein and the specific domains of LAM-1 are disclosed. Also disclosed are methods and agents for detecting, identifying and characterizing the LAM-1 ligand. The LAM-1 protein or a ligand binding fragment thereof or an antagonist to the LAM-1 protein or ligand binding fragment thereof are used in methods of detecting sites of inflammation or disease in a human patient. They are also used in therapeutic compositions in methods of treating a patient suffering from a leukocyte-mobilizing condition.