发明名称 NEW USE OF SUBSTITUTED QUINOLINE CARBOXAMIDE
摘要 The use of an anti-MS quinoline-3-carboxamide compound comprising the structure of formula (I), optionally with substituents for the H<1-9> hydrogen, or a salt of said compound where (a) ------------- represents that there are two conjugated double bonds between atoms comprised by the dashed line (only formula I), (b) the hydrogens H<7> and H<8> are attached to different atoms selected from X1, X2 and the nitrogen atom in the quinoline ring, (c) X1 and X2 are independently selected from an oxygen atom or an NH<9> group, said X1 and X2 being bound by a single bond to the ring when carrying H7 or H8 and by a double bond when not carrying H<7> or H<8>, for the manufacture of a composition intended for the treatment of conditions associated with MS. Also described are treatment regimens for MS patients. The particularly preferred compound is roquinimex or a salt thereof.
申请公布号 WO9306829(A1) 申请公布日期 1993.04.15
申请号 WO1992SE00705 申请日期 1992.10.08
申请人 KABI PHARMACIA AB 发明人 ABRAMSKY, ODED;KARUSSIS, DIMITRIOS;LEHAMANN, DAN;SLAVIN, SHIMON
分类号 A61K31/47;A61P25/00;C07D215/54;C07D215/56 主分类号 A61K31/47
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