Process for the preparation of (S) (+)-2-ethoxy-4-{N-[1- (2-piperidino-phenyl)-3-methyl-1-butyl]amino carbonyl methyl}-benzoic acid and pharmaceutical compositions containing it

摘要

The invention relates to a process for the preparation of (S) (+)-2-ethoxy-4-{N-[1-(2-piperidino-phenyl)-3-methyl-1- butyl]amino carbonyl methyl}-benzoic acid and its salts with inorganic or organic acids or bases having valuable pharmacological properties, namely action against the intermediate metabolism of substances in the treatment of diabetes mellitus, which comprises a) reaction between an (S)-amine of formula I <IMAGE> with a carboxylic acid of general formula II <IMAGE> or b) obtaining a carboxy group in a compound (S) of general formula III <IMAGE> c) or reaction of an (S) compound of general formula (IV) <IMAGE> with a compound of general formula (V) Z-CH2-CH3 (V) d) or the enantioselective reduction of a compound of general formula (VI) <IMAGE> e) or the oxidation of an (S) compound of general formula (VII) <IMAGE> f) or the separation of an (S) enantiomer mixture of general formula (VII) <IMAGE> using an (R) enantiomer of general formula (IX) <IMAGE>