发明名称 |
NORMAL HUMAN GROWTH CONTROLLING RECEPTOR FOR TGF-BETA |
摘要 |
Type III TGF- beta receptor is identified in and purified from normal human embryonic palatal mesenchyme (HEPM) cells and the purified product characterized structurally and functionally. HEPM cells were found to express high levels of the type III TGF- beta receptor and were found to significantly down-regulate two classes of TGF- beta receptor binding site. Purification of the type III TGF- beta receptor from solubilized HEPM cell membranes by affinity chromatography yielded a biologically active protein of about 205 kd which specifically binds both the recombinant and natural forms of TGF- beta 1 and TGF- beta 2, with affinity dissociation constants in the picomolar range. |
申请公布号 |
JPH0543599(A) |
申请公布日期 |
1993.02.23 |
申请号 |
JP19890292520 |
申请日期 |
1989.11.13 |
申请人 |
ONCOGEN LP |
发明人 |
MARIO ENU RIYUUBAAN;TOOMASU JIEE BURAUN;ANSONII EFU PAACHIO |
分类号 |
C07K14/705;C07K1/22;C07K14/00;C07K14/71;C07K14/715;C12N15/09;C12P21/02;C12R1/91 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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