NOVEL QUINOLONE CARBOXYLIC ACID DERIVATIVES

摘要

The present invention relates to novel quinolone carboxylic acid derivatives of structural formula (I) and pharmaceutically acceptable salts thereof. These compounds also have a potent activity against both Gram-positive bacteria and Gram-negative bacteria, wherein R<1> is hydrogen or alkyl group having one to six carbon atoms, R<2> is alkyl group having one to four carbon atoms, haloalkylgroup having one to four carbon atoms, cycloalkylgroup having three to six carbon atoms, alkenyl group having two to four carbon atoms, or phenyl group which is optionally mono or disubstituted by fluorine atoms, X is hydrogen, halogen, alkyl group having one to four carbon atoms, alkenyl group having two to four carbon atoms, cycloalkyl group having three to six carbon atoms, or amino, A is N or C-Y, Y is hydrogen, halogen, hydroxy, methoxy, or methyl, Z is formula (a), wherein Q, R<3>, m and n are respectively defined as the above.