| 摘要 |
Organic nitrates, processes for preparing them as well as their use in the treatment of vascular diseases and especially in the treatment of angina. The said nitrates correspond to the following formula I: <IMAGE> in which: R represents especially a sulphur-containing residue and a sulphur-containing amino acid residue; A represents especially a CH2 group or a substituted amino acid; n is equal to 0 or 1 or greater than 1; Y represents an oxygen atom or a NH group and B represents especially a 1,4:3,6-dianhydrohexitol mononitrate residue, an itol nitrate residue or an inositol residue. The said organic nitrates are prepared by reacting: I. either a R-COOH type thioacid, in which R has the same meaning as above, with a derivative of formula II: (A)n-Y-B, in which A, Y, B and n have the same meaning as above, II. or a derivative of formula III: R-CO-(A)n, in which R, A and n have the same meaning as above, with a derivative of formula Y-B, in which Y and B have the same meaning as above, in an appropriate solvent and under non-epimerising conditions.
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