发明名称 |
New microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal. |
摘要 |
<p>Described is a process for producing a new immunosuppressant, a C-31 desmethyl, C-19/C-22 cyclic hemiketal biotransformation analog (Compound I) of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces, lavendulae ATCC No. 55209. Also disclosed is the C-31 methylated devivative (Compound II) of Compound I produced by enzymatic methylation using 31-O-desmethylimmunomycin O-methyl transferase, (DIMT), a methyl transferase enzyme. The macrolide immunosuppressants are useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants. <IMAGE></p> |
申请公布号 |
EP0526935(A1) |
申请公布日期 |
1993.02.10 |
申请号 |
EP19920202299 |
申请日期 |
1992.07.25 |
申请人 |
MERCK & CO. INC. |
发明人 |
SHAFIEE, ALI;KAPLAN, LOUIS;CHEN, SHIEH-SHUNG TOM;ARISON, BYRON H.;COLWELL, LAWRENCE F.;DUMONT, FRANCIS;GARRITY, GEORGE M.;GAGLIARDI, MAGDA M. |
分类号 |
C07H19/01;C12N1/20;C12P17/18;C12P19/44;C12R1/56;A61P37/06;A61K31/435;C07D498/22 |
主分类号 |
C07H19/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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