摘要 |
PURPOSE:To obtain a new allyltetraline type lignaneamide compound useful as a treating agent for pancreatitis because of excellent proteolytic enzyme inhibiting action thereof. CONSTITUTION:A lignaneamide expressed by the formula (R is H, acetyl or 1-6C alkyl). The compound can be isolated from CANNABIS SEMEN (fruit of Cannabis sativa L . belonging to Moraceae) of a gelenical drug through (i) extraction by water, methanol, acetone, ethyl acetate and/or methylethyl ketone, (ii) partitioning extraction using a low-polar solvent, (iii) partitioning extraction using ethyl acetate, butanol and/or methylethyl ketone and (iv) chromatography and (v) recrystalization or powdering and, as necessary, further subjected to methylation, reduction or acetylation. Furthermore, the compound can be administered as an oral agent or parenteral agent without special limitation administration form. Dose of the above-mentioned compound for exhibiting its expected effects as the oral agent is normally 10mg to 1g per day for adult and preferably administered by dividing several portions. |