发明名称 |
BICYCLIC FIBRINOGEN ANTAGONISTS |
摘要 |
This invention relates to compounds of formula (I), wherein A<1> to A<5> form an accessible substituted seven-membered ring, which may be saturated or unsaturated, optionally containing up to two heteroatoms chosen from the group of O, S and N wherein S and N may be optionally oxidized; D<1> to D<4> form an accessible substituted six membered ring, optionally containing up to two nitrogen atoms; R is at least one substituent chosen from the group of R<7>, or Q-C1-4alkyl, Q-C2-4alkenyl, Q-C2-4alkynyl, preferably substituted by an acidic function; R* is H, Q-C1-6alkyl, Q-C1-6oxoalkyl, Q-C2-6alkenyl or Q-C2-4alkynyl, C3-6cycloalkyl, Ar or Het, optionally substituted by one or more substituents; and R<6> is preferably a substituent containing a basic nitrogen moiety; or a pharmaceutically acceptable salt thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation. |
申请公布号 |
WO9300095(A2) |
申请公布日期 |
1993.01.07 |
申请号 |
WO1992US05463 |
申请日期 |
1992.06.26 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
BONDINELL, WILLIAM, EDWARD;CALLAHAN, JAMES, FRANCIS;HUFFMAN, WILLIAM, FRANCIS;KEENAN, RICHARD, MCCULLOCH;KU, THOMAS, WEN-FU;NEWLANDER, KENNETH, ALLEN |
分类号 |
A61K31/55;A61K31/551;A61K31/5513;A61K31/675;A61K31/69;A61P7/02;A61P9/08;A61P9/10;C07D223/16;C07D243/12;C07D243/14;C07D267/14;C07D281/10;C07D471/04;C07D491/048;C07F9/40 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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