发明名称 |
Modified hepatitis B virus surface antigen P31 and production thereof |
摘要 |
A modified protein (i) derived from a hepatitis B virus surface antigen P31 protein and (ii) having hepatitis B virus surface antigen activity and the ability to bind polymerized human serum albumin, wherein the modification comprises rendering at least one trypsin-like protease sensitive site of the hepatitis B virus surface antigen P31 protein insensitive. The modified protein can be used in the production of a vaccine for prevention of hepatitis B virus infections and as an antigen for diagnosis of hepatitis B virus infections.
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申请公布号 |
US5164485(A) |
申请公布日期 |
1992.11.17 |
申请号 |
US19900547948 |
申请日期 |
1990.07.03 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
YUKIO, FUJISAWA;YASUAKI, ITOH;OSAMU, NISHIMURA;TOMOKO, FUJII |
分类号 |
A61K39/00;C07K14/02;C12N15/81;C12N15/85 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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