ANTIVIZAL DIBENZOTHIAZEPINONE DERIVATIVES

摘要

Compounds of formula (I) wherein n is 0, 1 or 2; and R<1> and R<2>, which may be the same or different, each represent one or more ring substituent(s) selected from: hydrogen, hydroxy, halogen, cyano, nitro, C1-6alkyl, C3-6cycloalkyl or C1-6alkoxy (where the alkyl or cycloalkyl moiety may be optionally substituted by one or more substituents selected from halogen atoms and hydroxyl groups); -NR<4>R<5> where R<4> and R<5>, which may be the same or different, each represent hydrogen or C1-6alkyl; -S(O)mR<6>, where m is 0, 1, 2 or 3 and R<6> represents hydrogen, C1-6alkyl or C3-6cycloakyl; -SO2NR<4>R<5> where R<4> et R<5> are each as defined above; phenyl, phenylC1-3alkoxy or phenylC1-3alkyl where the phenyl group may be optionally substituted by one or more substituents independently selected from C1-6alkyl, C1-6 alkoxy, hydroxy, nitro, halogen and amino; and -CO2H or -COR<7> where R<7> is C1-6alkyl or C3-6cycloalkyl; R<3> represents hydrogen or C1-4alkyl; and esters, salts and other physiologically functional derivatives thereof; show activity as antiviral agents, for example against HIV. Certain of the compounds are novel.