发明名称 |
STYRYL-SUBSTITUTED HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE |
摘要 |
Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about 4 heteroatoms, said compound optionally substituted or polysubstituted, with the proviso that when said ring is polysubstituted, the substituents do not have a common point of attachment to said ring, and those compounds wherein no substituent on the heteroaryl group is a carboxy group or an ester group, and pharmaceutical compositions comprising such compounds. |
申请公布号 |
WO9218481(A1) |
申请公布日期 |
1992.10.29 |
申请号 |
WO1991US07698 |
申请日期 |
1991.10.15 |
申请人 |
RHONE-POULENC RORER INTERNATIONAL (HOLDINGS), INC. |
发明人 |
SPADA, ALFRED, P.;PERSONS, PAUL, E.;LEVITZKI, ALEXANDER;GILON, CHAIM;GAZIT, AVIV |
分类号 |
A61K31/40;A61K31/403;A61K31/404;A61K31/44;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61P9/10;A61P35/00;A61P35/02;A61P43/00;C07D209/08;C07D209/12;C07D209/18;C07D213/54;C07D213/57;C07D213/89 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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