MODULATION OF tPA ACTIVITY BY HEPARIN FRAGMENTS

摘要

Disaccharides or oligosaccharides which include disaccharide subunits containing at least two negatively charged residues and fragment mixtures formed by partial or complete depolymerization of heparin by nitrous acid are capable of enhancing the ability of endogenous or administered tPA to dissolve blood clots. Disaccharide units which include, in particular, at least two sulfate residues, lack anticoagulant activity but are effective in enhancing the fibrin-specific clotting dissolution activity of tPA.