发明名称 |
Octapeptide or heptapeptide derivatives, a process for preparing them as well as medicaments containing these compounds and the use of them. |
摘要 |
<p>A subject matter of the invention are octapeptide or heptapeptide amide derivatives of formula <CHEM> wherein X1 stands for an aromatic D-amino acid rest; or a D-phenylglycyl, p-hydroxyphenylglycyl, o-aminobenzoyl, m-aminobenzoyl, D-tetrahydroisoquinolylcarbonyl or sarcosylalanyl; or a <CHEM> group, in which latter A1 means the rest of an amine or means an amino group or means an alkoxy, aryloxy or aralkyloxy group; X2 represents an aromatic amino acid rest or a histidyl group; X3 means a D-tryptophyl, o-aminobenzoyl, m-aminobenzoyl, aspartyl, D-aspartyl, beta -aspartyl, beta -D-aspartyl or aminosuccinyl group; or a group indicated for X1; X4 stands for an amino acid rest bearing an alkyl or aralkyl side chain; or a prolyl or beta -alanyl group; or a valence bond; X5 means an aromatic amino acid rest or a threonyl group; R1 represents hydrogen or a <CHEM> group, in which latter A2 means hydrogen or an alkyl group; R2 means hydrogen, -S- or a -S-acetamidomethyl, phenyl or p-hydroxyphenyl group; R3 stands for hydrogen or hydroxyl; R4 means a phenyl or p-hydroxyphenyl group; or -S-or a -S-acetamidomethyl group when the meaning of R2 is the same group; or a methyl group when R3 is hydroxyl and n is 1, 2, 3 or 4 and acid addition salts thereof. o</p> |
申请公布号 |
EP0505680(A1) |
申请公布日期 |
1992.09.30 |
申请号 |
EP19920101196 |
申请日期 |
1992.01.27 |
申请人 |
BIOSIGNAL KUTATO-FEJLESZTO KFT. |
发明人 |
KERI, GYOERGY, DR.;MEZOE, IMRE, DR.;HORVATH, ANIKO, DR.;VADASZ, ZSOLT, DR.;TEPLAN, ISTVAN, DR.;BALOGH, AGNES;CSUKA, ORSOLYA, DR.;BOEKOENYI, GYOENGYI;SZOEKE, BALAZS, DR.;HORVATH, JUDIT, DR.;IDEI, MIKLOS, DR.;SEPROEDI, JANOS, DR. |
分类号 |
A61K38/04;A61K38/00;A61P35/00;C07K1/04;C07K1/113;C07K7/02;C07K7/06;C07K14/575;C07K14/655 |
主分类号 |
A61K38/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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