| 摘要 |
PURPOSE: To obtain a pharmaceutical composition containing, as an effective ingredient, an N-(1-hexahydroazepinylalkyl)acetamide compound that has a cholinergic transmission effect by strongly stimulating release of acetylcholin. CONSTITUTION: This pharmaceutical composition, which is used for therapeutic treatment of cholinergic transmission disturbance, Alzheimer's disease, aging- related cerebropathies, and myastheniae without side effects, contains a compound of formula I (R is H or an alkyl; (n) is 0-4; R1 and R2 are each an alkyl, alkenyl, cycloalkyl, cycloalkenyl, aralkyl, heteroaryl or heteroaralkyl), its isomer or pharmacologically permissible acid adduct [for example, cyclohexyl N-[3-(1- hexahydroazepinyl)-propyl]-thien-3-ylacetamide, etc.]. |
