发明名称 |
Method of immobilizing an enzyme in a bundle of cellulosic fibres for a fibre-bundle dialyzer for purifying blood. |
摘要 |
<p>The object of the method is to immobilize a desired enzyme on the lumen surfaces of the dialyzer fibres typically having an inner diameter of 200-300 microns and wall thickness of 10-20 microns, without prejudice to the chemicophysical, dialyzing and bio-compatibility properties of the fibres.
<??>The enzyme is anchored directly or indirectly through covalent bonds upon activation of the lumen surfaces by circulation through the lumens of an aqueous solution of sodium periodate at a concentration of 0.7 - 21 mg/ml, at a circulation rate of 300-500 mm<3>/minute referred to 1 mm<2> of cross-sectional area of the lumen, at 15-30 DEG C for a time not exceeding 70 minutes. </p> |
申请公布号 |
EP0034304(A2) |
申请公布日期 |
1981.08.26 |
申请号 |
EP19810100791 |
申请日期 |
1981.02.05 |
申请人 |
SORIN BIOMEDICA S.P.A. |
发明人 |
CALLEGARO, LANFRANCO;BONIOLO, ANTONIO;DENTI, ENNIO;ROSA, UMBERTO;ROSSI, VALDANO |
分类号 |
A61M1/36;B01D67/00;B01D69/14;C12N11/12;F16L27/04;(IPC1-7):12N11/12;61M1/03 |
主分类号 |
A61M1/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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