发明名称 |
DISPLAY PHAGE |
摘要 |
2105303 9215679 PCTABS00016 The present invention relates to libraries of display phage which display various mutant epitopic peptides or protein domains with potential to bind to a target material of interest. Site-specific protease cleavable linkers may be incorporated into these phages to overcome the problem of irreversible binding to target materials. When the displayed insert is a mini-protein, a reagent which cleaves the crosslink may be used to facilitate release of a tightly bound display phage. The invention also relates to providing a more balanced library of epitopic peptide display phage.
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申请公布号 |
CA2105303(A1) |
申请公布日期 |
1992.09.02 |
申请号 |
CA19922105303 |
申请日期 |
1992.02.28 |
申请人 |
PROTEIN ENGINEERING CORPORATION |
发明人 |
MARKLAND, WILLIAM;ROBERTS, BRUCE L.;LADNER, ROBERT C.;LEY, ARTHUR C. |
分类号 |
C07K14/005;A61K38/00;A61Q11/00;C07K1/00;C07K1/04;C07K1/107;C07K14/00;C07K14/435;C07K14/705;C07K14/81;C12N7/00;C12N7/01;C12N15/09;C12N15/10;C12N15/12;C12N15/62;C12N15/63;C12N15/66;C12N15/70;C12P21/00;C12P21/02;C12Q1/70;C40B40/02;G01N33/53;G01N33/554;G01N33/566;(IPC1-7):C12N7/01 |
主分类号 |
C07K14/005 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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