METHOD AND MEANS FOR EXTENDING THE HOST RANGE OF INSECTICIDAL PROTEINS

摘要

The invention relates to a method for increasing the host range or toxicity of an insecticidal protein exerting its activity via interaction with the gut epithelium of insects within its host range, by delivering the insecticidal protein to the gut epithelium of a target insect with the aid of an other, targeting protein capable of binding to the gut epithelium of the target insect. The targeting protein may, for example, be of viral origin or, alternatively, may be a bacterial protein or protein domain having high affinity for the lipid components of membranes.