N-IMIDAZOLYL DERIVATIVES OF SUBSTITUTED ALKOXYIMINO TETRAHYDRO-NAPHTHALENES AND CHROMANS

摘要

1. The invention provides new imidazole containing alkoxyimino derivatives of tetrahydronaphthalene and chroman of general formula (I) I wherein Z is -CH2-or-O-; m is an integer of 1 to 4; n is zero or 1; T is a straight or branched, saturated-or unsaturated C1-C6 hydrocarbon chain, or a phenylene radical; is a bond or a divalent group consisting of-Si(R'R'')-; -O-CH2-, -CF2-,C(R'R'')-,vinylene or isopropenylene, wherein each of R' and R'' being the same or different is hydrogen or C1-C4 alkyl; R is hydrogen or C1-C4 alkyl; R1 and R2, being the same, are hydrogen or methyl, or one of R1 and R2 is hydrogen and the other is a) a C1-C6 alkyl group; b) a C5-C6 cycloalkyl or C5-C6 cycloalkyl-C1-C4 alkyl group, wherein the cycloalkyl group or moiety is unsubstituted or substituted by 1 to 4 C1-C4 alkyl groups; or 2. c) an aryl or aryl-C1-C4 alkyl group, wherein the aryl group or the aryl moiety is unsubstituted or substituted by 1 to 4 substituents independently chosen from halogen, hydroxy, C1-C4 alkyl, trihalo-C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio and C1-C4 alkylsulfonyl; R3 is hydrogen or a substituent chosen from halogen, hydroxy, C1-C4 alkyl, trihalo-C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio and C1-C4 alkylsulfonyl; R4 is an -OR5 or -N(R5 R6)group, wherein each of R5 and R6 independently is hydrogen, C1-C6 alkyl, phenyl or benzyl; and the pharmaceutically acceptable salts thereof, which are useful in the treatment of a disease state in which an anhancement of TxA2 synthesis exerts a pathogenic effect.