| 摘要 |
The technical field of the invention relates to: (1) certain photosensitive substances used with lasers for discovery and destruction of tumors; (2) methods of making the substances; (3) use of the substances; and (4) certain light-delivery equipment used with the substance. To obtain tumor-selective, photosensitizing substances useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. Other photosensitizing materials may be combined with a carrier that enters undesirable tissues and cells of the reticular endothelial system such as macrophages. These photosensitizing materials: (1) must have a triplet energy state above 3.5 kilocalories per mole; (2) cannot be easily oxidized; and (3) not physically quench any required energy state. Preferably, this photosensitizing material should be lipophilic. The substance is injected into the patient, clears normal tissue and then neoplastic tissue is irradiated using lasers. Laser equipment includes a light conductor and transmitting head with light differing surface and feedback path for radiated light related to dosage.
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