发明名称 |
Renin inhibitors containing alpha -heteroatom amino acids |
摘要 |
The invention concerns novel renin-inhibitory peptides which contain novel amino acids having an alpha -heteroatom attached to the backbone of the amino acid. <IMAGE> These novel amino acids are positioned at the P2 position of the peptide. These are useful for treating renin-associated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Novel intermediates are also disclosed. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
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申请公布号 |
US5126451(A) |
申请公布日期 |
1992.06.30 |
申请号 |
US19910677007 |
申请日期 |
1991.03.28 |
申请人 |
WARNER-LAMBERT COMPANY |
发明人 |
KALTENBRONN, JAMES S.;REPINE, JOSEPH T. |
分类号 |
C07C233/51;C07C237/22;C07C271/22;C07C317/50;C07C323/59;C07C323/60;C07C335/08;C07D295/26;C07K5/02 |
主分类号 |
C07C233/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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