发明名称 |
ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR HAEMOPHILUS INFLUENZAE |
摘要 |
2098598 9210936 PCTABS00014 Disclosed herein are immunogenic polysaccharide-H. influenzae adhesin protein conjugates, a purified H. influenzae adhesin protein and related proteins and polypeptides, DNA useful for producing the proteins, synthetic polyribosylribotol phosphate (PRP) oligosaccharides and intermediates useful for their synthesis, and methods of making and using these materials. The conjugates comprise a PRP fragment, preferably a synthetic oligosaccharide, coupled to an H. influenzae adhesin protein. The invention further comprises purified H. influenzae adhesin proteins and novel PRP oligosaccharides. The invention also comprises methods of producing these materials and using them in a vaccine to protect humanS md other mammals against H. influenzae infection.
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申请公布号 |
CA2098598(A1) |
申请公布日期 |
1992.06.22 |
申请号 |
CA19912098598 |
申请日期 |
1991.12.20 |
申请人 |
MICROCARB, INC. |
发明人 |
KRIVAN, HOWARD C.;SAMUEL, JAMES E.;NORBERG, NILS T. |
分类号 |
A61K39/145;A61K39/102;A61P31/12;A61P31/16;C07H15/04;C07H15/08;C07H15/18;C07K1/00;C07K1/113;C07K1/22;C07K14/00;C07K14/11;C07K14/195;C07K14/285;C07K14/41;C07K14/705;C07K19/00;C12N1/21;C12N15/09;C12P21/00;C12P21/04;C12R1/19;(IPC1-7):C12N15/31;C07H15/26 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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