| 发明名称 |
Genes encoding the human FK-506 binding protein and a S. cerevisiae homolog, FKB1, and their expression. |
| 摘要 |
<p>The genes encoding the human FK-506 binding protein and a S. cerevisiae homolog, FKB1, are described, as well as their expression and the amino acid sequences of the protein products. These binding proteins are useful, inter alia, for screening compounds useful as immunosuppressive drugs that block allograft rejection by preventing T-cell activation. <IMAGE> <IMAGE> <IMAGE></p> |
| 申请公布号 |
EP0481673(A2) |
申请公布日期 |
1992.04.22 |
| 申请号 |
EP19910309299 |
申请日期 |
1991.10.09 |
| 申请人 |
MERCK & CO. INC. |
发明人 |
SIEKIERKA, JOHN J.;WIEDERRECHT, GREGORY J. |
| 分类号 |
A61K38/00;A61P37/06;C07K14/37;C07K14/41;C07K19/00;C12N1/21;C12N9/90;C12N15/09;C12N15/60;C12N15/61;C12P21/02;C12R1/19;C12R1/865;C12R1/91;G01N33/53 |
主分类号 |
A61K38/00 |
| 代理机构 |
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代理人 |
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