GENES ENCODING THE HUMAN FK-506 BINDING PROTEIN AND A.S. CEREVISIAE HOMOLOG, FKB1 AND THEIR EXPRESSION

摘要

9944P 18243 TITLE OF THE INVENTION GENES ENCODING THE HUMAN FK-506 BINDING PROTEIN AND a S. CEREVISIAE HOMOLOG, FKB1, AND THEIR EXPRESSION The genes encoding the human FK-506 binding protein and a S. cerevisiae homolog, FKB1, are described, as well as their expression and the amino acid sequences of the protein products. These binding proteins are useful, inter alia, for screening compounds useful as immunosuppressive drugs that block allograft rejection by preventing T-cell activation.