| 摘要 |
3-SUBSTITUTED-AMINOMETHYL-3-SUBSTITUTED-OXY-17A-METHYL-17A-LOWER-ALKYL-17A-AZA-D-HOMOL-5-ALPHA-ANDROSTANES This invention pertains to novel 3-substituted-aminomethyl-3-substi-tuted-oxy-17a-methyl-17a-lower-alkyl-17a-aza-D-homo-5-alpha-androstane compounds useful as muscle relaxants, methods for preparing such compounds, and methods for administering muscle relaxation, wherein the novel compounds are represented the general Formula: (1) including optically active isomeric forms, and pharmaceutically acceptable acid addition salts thereof, therein: R is selected from the group consisting of hydrogen, lower-alkyl, lower-alkyl carbonyl, and di(lower-alkyl)amino carbonyl; R1 is selected from the group consisting of: di(lower-alkyl)sub-stituted amino; lower-cycloalkyl lower-alkyl, lower-alkyl substituted amino;, 1-piperidinyl; 1-pyrrolidinyl; 1-hexamethyleneimino; 4-morphol-inyl; 1-piperazinyl, 1-(4-methylpiperazinyl), tri(lower-alkyl)substituted amino, 1-(1-methylpiperidinyl); 1-(1-methylpyrrolidinyl); and 1-(4,4-di-methylpiperazinyl). each lower-alkyl group having from 1 to 6 carbon atoms; R2 is a lower-alkyl group having from 1 to 4 carbon atoms; and Xis a pharmaceutically acceptable anion.
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