摘要 |
NEW MATERIAL:A compound expressed by formula I [A is H or 2-18C hydrocarbonacyl subsituted by amino group at the alpha-position; B is F, Gly (F is neutral alpha-amino acid residue), NH or (CH2)nCO (n is 1-4); C is neutral alpha-amino acid residue; # is L-Arg or D-Arg and # is D-Arg when A is H; B is Gly-Gly and C is Met or Ile). EXAMPLE:A compound expressed by formula II. USE:A remedy for hypertension, diuretic agent and remedy for diseases in cardiac.cerebral circulatory organs having powerful hypotensive and sodium diuretic action. PREPARATION:A compound expressed by formula III is synthesized by a peptide synthetic method and then oxidized with air, potassium ferricyanide, iodine, diidoethane, etc., in a solvent, e.g. water, etc., The above-mentioned oxidative reaction is preferably carried out at 0-40 deg.C and pH 6-7.5 by a high dilution method. |