THIOETHER, VERFAHREN ZU DEREN HERSTELLUNG SOWIE DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL.

摘要

Phenoxyalkyl-thio-ether and sulphoxide derivs. of formula (I) and their pharmaceutically acceptable salts are new. Ar = phenyl, opt. substd. by 1-3 of alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, OH, hydroxyalkyl, COOH, alkoxycarbonyl, CONH2, NO2, NH2 or halo; A = 1-8C alkenyl, opt. unsatd. and/or substd. by OH; n = 0, 1 or 2; B = 1-8C alkenyl, opt. unsatd.; R = 5-(1H)-tetrazolyl -CONH-tetrazolyl, -CO-N(OH)R1, CN, SCN, OH, halo 5-mercaptotetrazolyl or R1 = H, alkyl (opt. substd. by cycloalkyl), alkenyl, cycloalkyl or aralkyl. (I) can be prepd. by (1) Ar-O-A-X + Y-B-G (one of X and Y = SH, the other is a reactive gp.; G = R or OH (sic)). (2) An acid of formula ArO-A-S-B-COOH (or its reactive derivs.) is reacted with 5-amino-tetrazole or HN(OH)R. (3) Cpds. where G = OH, can be converted to a reactive gp. (e.g. halide or tosylate) and this exchanged for other values of R, and cpds. with n = 0 can be oxidised conventionally.