PACAP38, proteine with adenylate cyclase activity.

摘要

Disclosed are (1) a genomic DNA of human PACAP38; (2) a DNA containing a DNA segment coding for human PACAP38; (3) a transformant bearing a DNA containing a DNA segment coding for PACAP38; and (4) a method for preparing a mature PACAP38 protein comprising cultivating the transformant described in the above (3), accumulating the protein in a culture product, and collecting the resulting protein. The DNA makes it possible to screen the chemical substance necessary for production of PACAP and is applied to experimental animals to understand their brain functions, which serves to elucidate human brain functions. Human PACAP38 can also be utilized as therapeutic agents about growth and maintenance of human brain nerves.