| 摘要 |
PCT No. PCT/GB87/00106 Sec. 371 Date Dec. 14, 1987 Sec. 102(e) Date Dec. 14, 1987 PCT Filed Feb. 13, 1987 PCT Pub. No. WO87/05030 PCT Pub. Date Aug. 27, 1987.A conjugate compound has the structure (I), wherein R1 is -(CH2)p-R6-(CH2)q- where p and q are the same or different and are 0, 1 or 2, and -R6- is -(CH2)n-, where n is 0 or 1, -NH-, -O-, -S- or (II), R1 optionally being alkyl substituted, provided that neither p nor q is 0 unless R6 is -CH2-; R2 are -CH2CH2- or -CH2CH2CH2-, optionally alkyl, alkoxyalkyl or hydroxyalkyl substituted; R3 are the same or different and are -H, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, carboxyalkyl ester, phosphate, sulphonate or phosphonate; R4 is one of the compounds of formula (III) optionally alkyl substituted, wherein R7 is -H, alkyl, hydroxyalkyl, or alkoxyalkyl provided that when R4 is (III d), R3 is not carboxyalkyl, R5 is a linker, and Ab is an antibody. The conjugate compound provides for complexes of metals such as Tc, Co, Re, Cu, Au and Ag which are useful reagents for in vivo imaging and therapy.
|
