PHTHALOCYANINE PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND METHODS FOR THEIR SYNTHESIS AND USE

摘要

The present invention relates to a series of novel phthalocyanine compositions (or compounds) suitable for use as photosensitizers for photodynamic therapy. Specifically, the invention relates to a series of new aluminum (Al) and/or silicon (Si) phthalocyanines having substituted amine or quaternary ammonium axial ligands attached to the central metal, and the use of these new phthalocyanine compositions for the treatment of cancer through photosensitization. Moreover, the present invention is directed to the methods of preparing these compositions for use in photodynamic therapy. The phthalocyanine compounds have formula (I), wherein M = AlOSi(CH3)2(CH2)3N(CH3)2; AlOSi(CH3)2(CH2)3N(CH3)3+I-; HOSiOSi(CH¿3?)2(CH2)3N(CH3)2, or HOSiOSi(CH3)2(CH2)3N(CH3)3?+I-¿.