发明名称 |
FREMGANGSMAATE FOR FREMSTILLING AV 1,2-DIHYDRO-3H-PYRROLO-(1,2-A)-PYRROL-1,7-DICARBOXYLSYRE OG DENNES LAVERE DIALKYLESTERE |
摘要 |
Novel, racemic 1-(substd.-amino-methyl) -octa-hydro-indole-(2,3-a)-quinolizine derivs. (i) and their pharmaceutically useful acid adduct salts are prepd. from 1-(substd.-sulphonyl-oxy-methyl)-octa-hydro-indolo(2,3-a)-quinoli- zine derivs. (ii) and a prim. amine of formula R2-NH2. (iii) R2 in (1) and (iii) = 1-6C alkyl, 4-8C cycloalkyl or opt. substd. aryl and aralkyl or an aralkyl gp. opt. contg. heteroatom. R1 = 1-6C substd. alkyl or aryl gp. The reaction takes place in an inert organic solvent at its opt. acid adduct salts are pred. The prepns. have a gasto-cytoprotective effect. |
申请公布号 |
NO169124(B) |
申请公布日期 |
1992.02.03 |
申请号 |
NO19880000127 |
申请日期 |
1988.01.13 |
申请人 |
SYNTEX (USA) INC |
发明人 |
KHATRI, HIRALAL N.;FLEMING, MICHAEL P.;SCHLOEMER, GEORGE C. |
分类号 |
A61K31/395;C07D207/22;C07D207/34;C07D455/00;C07D471/04;C07D487/04 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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