Triptolide derivatives as immunomodulators and anticancer agents

摘要

Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, R¹ is H or R, R being selected from lower alkyl, alkenyl, alkynyl, and allenyl, or, R¹ together with R²=O (oxo); R²=OH, or, R¹ and R² together=O (oxo); CR³R⁵ and CR⁴R⁶ are selected from CH₂, CHOH and CROH; at least one of R¹, R⁵ and R⁶ is R; and at least one of CR³R⁵ and CR⁴R⁶ is CH₂.