Neutral tasting tablets and granules contg. Mesna - contain binder, disintegrating agent, lubricant filler and opt. effervescent mixt.

摘要

Tablets contg. mesna as the active ingredient and opt. conventinal flavourings, sweeteners and perfumes also contain per pt. wt. mesna, 0.01-1 pts. wt. of a binder, 0.03-0.4 pts. wt. of a disintegrating agent, 0.01-0.2 pts .wt. of a lubricant, 0.1-1 pts. of a lubricant 0.1-1 pts. wt. of a filler and, in the case of effervescent tablets, an additional 0.05-30 pts. wt. of a conventional physiologically acceptable effervescent mixt. USE/ADVANTAGE - Mesna is used to protect the urinary tract in the therapy of tumour diseases using ifosfamide. Mesna is also used as a mucolytic. Mesna is a white hygroscopic powder with a characteristic taste and is very sensitive to oxidn. and, on contact with oxygen, esp. in damp atmos. rapidly turns into dimesna. The invention overcomes previous problems in formulating mesna or a mixt. of i-PrOH and water and the granulate can then be worked up to give tablets or coated tablets which have good chemical stability, are easy to take and, when immediately swallowed are practically neutral in taste.