VERWENDUNG VON OXOCHINAZOLINDERIVATEN BEI DER BEHANDLUNG VON HYPERURIKAEMIE.

摘要

Tricyclic quinazolones of formula (I) or (II) or their salts are used in the treatment of hyperuricaemia: A = CH=CH, CH=N or S; R1 = (a) H, lower alkyl, lower alkoxy or a fused benzene ring , or (b) CN, 5-tetrazolyl or COR3; R2 = CN, 5-tetrazolyl or COR4, or may also be H, lower alkyl, lower alkoxy or a fused benzene ring when R1 = (b); R3 = lower alkoxy, NH2, NHOH or 5-tetrazolylamino, or may also be OH when R2 is not H (but 11-oxo-11H-pyrido(2,1-b) quinazoline-8-carboxylic acid is specifically disclosed); R4 = OH, lower alkoxy, NH2, NHOH or 5-tetrazolylamino; R5 + R6 or R7+R8 = N=N-NH, the other gps. R5-R8 being H, lower alkyl, lower alkoxy or a fused benzene ring. (I) and (II) are described in DE2557425 and EP113911.