发明名称 |
INHIBITORS OF ASPARTIC PROTEASES |
摘要 |
Compounds useful as inhibitors of retroviral proteases characterized by the structure (I), wherein the X<1> and X<2> groups may consist of 0 to 2 alpha -amino acid groups terminally substituted by hydrogen or one of a number of end groups, and the R<1> and R<2> group can be selected from a wide variety of hydrocarbon radicals. Compounds which exhibit a protease activity inhibition constant Ki of less than 50 mu M are desired. |
申请公布号 |
WO9200956(A1) |
申请公布日期 |
1992.01.23 |
申请号 |
WO1991US04758 |
申请日期 |
1991.07.03 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
DREYER, GEOFFREY, BAINBRIDGE;GLEASON, JOHN, GERALD |
分类号 |
A61K31/16;A61K31/40;A61K31/403;A61K31/404;A61K31/415;A61K31/4184;A61K31/66;A61K38/00;A61K38/55;A61P31/12;A61P43/00;C07C237/10;C07C271/16;C07C271/22;C07C317/28;C07C317/44;C07C323/29;C07D209/14;C07D213/36;C07D233/61;C07D235/08;C07D295/12;C07F9/44;C07K5/02;C07K5/06;C07K5/065;C07K5/072;C07K14/81 |
主分类号 |
A61K31/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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