Amino bicyclic compounds.

摘要

The present invention is concerned with compounds of formula (I) <CHEM> wherein X is a sulphur atom or oxygen atom or a group -NR<1>- or -CR<1>R<2>-, in the alpha- or beta-configuration, where R<1> and R<2> are hydrogen or straight or branched C1-5 alkyl; X<1> is a C1-5 straight chain or branched alkylene group, a C3-5 straight chain or branched alkenylene group or a substituted or unsubstituted C6 or C10 aromatic group, the optional substituents on the aromatic group being one or more of C1-4 alkyl, C1-4 alkoxy, nitro, halo and trihalomethyl; X<2> is a cyano, carboxyl, carboxamide, hydroxymethyl, C2-5 alkoxycarbonyl, or 5-tetrazolyl group; Z<1> is a group selected from -NH-CH2-R<3> and -N=CO-R<3> wherein R<3> is a group selected from -CO-Y and -CH(Y<1>)Y, Y being a group selected from C3-8 alkyl, C3-8 alkenyl, phenyl-C1-4 alkyl and phenyl (wherein the phenyl group in both cases is optionally substituted by one or more groups independently selected from C1-4 alkyl, C1-4 alkoxy, nitro, halo and trihalomethyl), cycloalkyl of from 4 to 8 carbon atoms and 5- and 6-membered heterocyclic radicals containing at least one oxygen, sulphur, or nitrogen heteroatom and Y<1> being a group selected from hydroxy, hydrogen, C1-4 alkoxy and C1-5 alkanoyloxy; Z<2> is hydrogen, C1-12 alkyl (straight or branched), C2-12 alkenyl or alkynyl, C6 or C10 aryl or C6 or C10 aryl-C1-12 alkyl wherein the aryl group is optionally substituted by one or more groups independently selected from phenyl, C1-4 alkyl, C1-4 alkoxy, nitro, halo and trihalomethyl) or cycloalkyl of from 3 to 5 carbon atoms; and salts, esters and other physiologically functional derivatives thereof. The preparation of these compounds, medicaments containing them and their use as therapeutic agents are also within the scope of the invention.