| 摘要 |
Use of a phenyl pyrimidine deriv. of formula (I) or its salts for the mfr. of a medicament for treating CNS disorders or diseases is new: R1, R2 = H, halo, OH, alkyl, alkoxy, alkylthio, or NR'R''; R', R'' = H, alkyl, aryl or aralkyl; or NR'R'' = heterocyclyl opt. contg. a further heteroatom and opt. substd. by alkyl; R3 = H, alkyl (opt. substd. by halo), NH2, alkylamino, dialkylamino, CN, NO2, halo, carbamoyl, OH, COOH, alkoxy, alkylthio, alkylthioalkyl S(O)n-alkyl, di(alkoxy)alkyl, CRNOH, COR, CO2R or CH2X; R = H or alkyl; X = OH, alkoxy, aryloxy, aralkoxy, halo, CN, NR'R'', S(O)n-alkyl or SO2N(R)2; n = 1-2; R4-R8 = H, halo, alkyl, perhaloalkyl, CN, carbamoyl, COOH, COR, NO2, NH2, alkylsulphonylamino, alkoxy, S(O)n-alkyl or SO2N(R)2; or R4 + R5 or R5 + R6 = CH=CH-CH=CH or (CH2)4; and R7, R8 = H; one of the N on the pyrimidine ring is opt. N-alkylated or an N-oxide; alkyl = 1-6C; aryl = 6-10C. (I) are new provided that at least one of the R4-R8 is not H and when R1 = R2 = NH2 or R1 = OH and R2 = NH2, R3 = H or alkyl and R7 = H, then R4 and R5 are both halo. |
