Process for producing epoxyalcohols of high optical purity.

摘要

A process for enriching or improving the optical purity of an asymmetric epoxidation reaction mixture is provided wherein one chiral epoxy alcohol enantiomer, preferably the one present in minor amounts, is effectively separated from the other chiral epoxy alcohol enantiomer by converting the former to an epoxy ester by stereoselective transesterification using a carboxylic acid derivative such as an enol ester and a lipase enzyme and then recovering the desired chiral epoxy alcohol enantiomer or reacting it in situ to form a chiral epoxy alcohol derivative.